Healthy infant diet prevents metabolic changes in offspring, according to a study by CIBEROBN and UIB

Equipo del área de Obesidad y Nutrición del Centro de Investigación Biomédica en Red (CIBEROBN), con el profesor Andreu Palou, su responsable, en primera fila - Foto: A.Costa/UIB

According to a study by the Obesity and Nutrition team of the Center for Biomedical Research Network (CIBEROBN) and scientists from UIB published in the journal Molecular Nutrition and Food Research, a healthy diet during lactation prevents metabolic changes in the offspring.

These results highlight that restoring the mother’s healthy diet during lactation may at least partially prevent metabolic disturbances in the offspring caused by malnutrition and obesity during the prenatal stages.

The study was conducted by the UIB Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutritional Genetics, Biomarkers and Risk Assessment Group, NUBE) and the Institute of Health Research in the Balearic Islands (IDISBA) in collaboration with the Institute of Physiology. From the Czech Academy of Sciences.

In an animal model, normalization of the mother’s diet during lactation has been shown to prevent the adverse effects of the obesity-inducing diet on lipids or lipids (a group of hundreds of lipids) in breast milk and plasma before and during pregnancy. matter. about children


These new ideas suggest that restoring a healthy diet to the mother during lactation may prevent, at least in part, the metabolic disturbances caused by malnutrition and obesity during the prenatal stages.

Previous intervention studies in animal models have shown that consumption of an obese diet during the perinatal period affects mammary gland function, and thus milk composition, implying that these changes may be ‘programmed in the offspring’. And the

This programming leads to a greater tendency to develop chronic pathology in adulthood. Researchers have studied intervention strategies during breastfeeding to prevent negative effects from an unbalanced diet for the mother during or even before pregnancy.

To do this, they analyzed the lipid profile to identify changes in this profile that could be associated with increased disease risk in later stages of life, as well as plasma levels of offspring in later stages. He may also analyze the lipid profile. life. Breast feeding.

The results of this study showed that maternal consumption of an obesity-inducing diet during the perinatal period (specifically, 1 month before conception and during pregnancy and lactation) caused a significant change in the milk and plasma lipid composition of their infants. the reasons. Initial phase.

These changes were largely reflected in the milk of mothers who received a standard (balanced) diet during lactation, and in the plasma of their offspring. The reversal of these changes has been linked, at least in part, to a restoration of hormone expression levels.

This is the hormone adiponectin in the mammary gland. These changes are also associated with decreased expression of proinflammatory factors. The study authors, led by Dr. Catalina Pico, are studying how to apply these findings to humans.

In any case, they recommend extreme caution in feeding during lactation, as a critical period in which metabolic changes in the offspring that may have been poorly programmed by unhealthy feeding or lifestyle from the previous period can be corrected. Maybe he’s gone.

The CIBER Consortium (Biomedical Research Center Network, MP) is based on the Carlos III Institute of Health – the Ministry of Science and Innovation – and is co-financed by the European Regional Development Fund (ERDF). The Pathophysiology of Obesity and Nutrition (CIBEROBN) sector consists of 33 national groups.

These working groups of proven scientific excellence focus their research work on the study of obesity, nutrition, and physical exercise to generate knowledge useful to clinical practice, the food industry, and society at large.

The groups are also working on the benefits of the Mediterranean diet, prevention of metabolic disorders, obesity in children and adolescents, and the relationship between obesity and cancer. It is one of these groups that developed this latest research work at the University of the Balearic Islands.

bibliography reference

Pedro Castillo, Ondrej Koda, Jan Kubicki, Catalina Amadora Pomer, Andres Palo, Mariana Palo, Catalina Pico. Return to the zdravá diet during lactation normalizes breast milk fat content in diet-induced obese mice and prevents changes in plasma lipids of the offspring. Molecular Nutrition and Food Research. DOI: 10.1002 / mnfr.202200204

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